Brock Purdy Injury Uncertainty Impacts Rams Vs. 49ers Opening Odds For Nfl Week 10

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San Francisco 49ers backmost Brock Purdy missed his seventh crippled of nan play successful Week 9 against nan New York Giants, and his position is up successful nan aerial for a important Week 10 matchup pinch nan Los Angeles Rams.

NFL insider Ian Rapoport reported connected Sunday that Purdy has a chance to return to his starting occupation successful Week 10, but 49ers caput coach Kyle Shanahan did not look arsenic confident.

Shanahan admitted that Purdy’s turf toed wounded — which he suffered each nan measurement backmost successful Week 1 — is going to effect him for nan remainder of nan season.

He said that Purdy remains week-to-week, and that nan squad has nary volition successful rushing him backmost into action.

#49ers HC Kyle Shanahan revealed that QB Brock Purdy will beryllium managing his turf toed each season. 🩹

The squad will support evaluating him week to week, and Shanahan confirmed they won’t unreserved him back.

Looks for illustration it could beryllium nan Mac Jones show for a while. 👀 #FTTB pic.twitter.com/vuEZWrwVWJ

— 49ers & NFL News 24/7 (@49ersSportsTalk) November 2, 2025

As a result, nan 49ers person opened arsenic 3.5-point underdogs successful nan likelihood for Week 10 astatine DraftKings Sportsbook. This is simply a important matchup, arsenic nan 49ers (6-3) are bending nan Rams (6-2) successful nan NFC West standings.

It’s beautiful clear that Purdy is highly questionable for this game, arsenic nan 49ers are much than a section extremity underdog astatine home.

Even pinch Purdy missing astir of nan season, San Francisco has been capable to enactment afloat successful nan NFC acknowledgment to nan beardown play of erstwhile first-round prime Mac Jones.

In Week 9, Jones was terrific for San Francisco, completing 19 of his 24 walk attempts for 235 yards and 2 scores. He turned things astir aft a three-game agelong wherever he threw conscionable 2 scores and 4 picks while starring San Fran to a 1-2 mark.

The 49ers are firmly successful nan operation for a playoff spot successful nan NFC, but they whitethorn person a higher ceiling if Purdy returns, arsenic he has taken nan squad to nan Super Bowl earlier successful his career.

Purdy suffered his turf toed wounded against Seattle successful Week 1 and missed nan adjacent 2 games arsenic a result. He past aggravated nan rumor successful his return against nan Jacksonville Jaguars successful Week 4 and has not played since. 

That whitethorn beryllium why San Francisco is being truthful cautious pinch nan prima quarterback, arsenic it doesn’t want to suffer him for nan remainder of nan season.

The 49ers would apt move wrong a section extremity successful nan likelihood for this crippled if Purdy ends up returning successful Week 10.

Odds refresh periodically and are taxable to change.

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